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10.4.1.1 Time Averages. At this point, we will compute queue time averages based on the queue Palm probabilities computed in Theorem 10.4.1. For this we on need a stationary version as of the on=off arrival process at . Let Tn ; I < t n < I, be a stationary point process that represents the beginnings of the on=off on on periods, with a convention that T0 < 0 T1 . Then, according to Resnick and on on Samorodnitsky [51], the random variable T0 can be represented as T0 off on on on off B t 0 t0 1 B t 0 , where the random variables B, t 0 , t 0 are independent of fton ; toff ; n 1g; toff , B is a Bernoulli random variable with n n 0 P B 0 1 P B 1 Eton = Eton Etoff , and ton , toff are distributed as 0 0 integrated tail distributions of ton , toff , respectively. Furthermore, the net increment

Assessment and evaluation of toxic characteristics Select chronic dose levels. Useful information and permissible human exposure

No one can debate the effects of in uenza virus on the human condition In recent times, the defeat of Germany in World War I was in part related to an in uenza outbreak At detailed by Oldstone,1c Germany s spring 1918 offensive, after the withdrawal of Russia from the war, threatened the Allies with defeat However, in uenza brought about a massive loss of German troops and concurrent breakdown of logistics German Commander Eric von Ludendorff blamed in uenza for cessation of the German Army offensive This in turn permitted time for the in ux of the American Expeditionary Force, the accompanied regain of lost French soil, and an eventual armistice Yet in uenza, not the weapons of war, caused 80% of American casualties and 43,000 deaths.

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of the load that comes to the queue in the interval T0 ; 0 is given by the following equation: 0 as c dt B r c ton ctoff 1 B r c ton : 10:14 t 0 0 0

Fischer 344 rats B6C3F1 mice Three dose levels Ophthalmology Hematology Clinical chemistry Histology Target organs Five dose levels

10:15 10:16

Source: From the National Toxicology/Program, Washington, DC: Department of Health and Human Services. Report of the NTP Ad hoc Panel on Chemical Carcinogenesis Testing and Evaluation. Note: EPA, Environmental Protection Agency; FDA, Food and Drug Administration; IND/NDA, investigative new drug/new drug assessment; OECD, Organization for Economic Cooperation and Development; NTP, National Toxicology Program.

This experience was generalized expertly by Jared Diamond in Guns, Germs, and Steel1a: All those military histories glorifying great generals oversimplify the ego-de ating truth: the winners of past wars were not always the armies with the best generals and weapons, but were often merely those bearing the nastiest germs to transmit to their enemies Worldwide, the 1918 1919 in uenza epidemic (termed the Spanish u) infected a fth of the total human population at that time and killed an estimated 20 50 million people Other RNA viruses evoke concern Many of them have been the subject of press accounts over the past few decades and, in various modi ed embodiments, have become the stuff of novels and stars of lms alike Presently, human immunode ciency virus (HIV), with the resultant acquired immune de ciency syndrome (AIDS), is the most infamous example of a modern emerging infectious disease.

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A In-life Data Interim tests are carried out at intervals before the study to establish baselines, at intervals during the study, and at the end of the study 1 Appearance Mortality and morbidity as well as the condition of the skin, fur, mucous membranes, and ori ces should be checked at least daily Presence of palpable masses or external lesions should be noted 2 Eyes Ophthalmologic examination of both cornea and retina should be carried out at the beginning and at the end of the study 3 Food consumption Weekly 4 Body weight Weekly 5 Behavioral abnormalities 6 Respiration rate 7 ECG Particularly with the larger animals 8 EEG Particularly with the larger animals 9 Hematology Assessment should be made prior to chemical administration (pretest) and at least prior to termination Hemoglobin, hematocrit, RBC, WBC, differential counts, platelets, reticulocytes, and clotting parameters should be assessed 10 Blood chemistry.

10:17

2 There were 38 million HIV-infected humans in 2003, and nearly ve million people became infected with HIV in 2003, more than any year before Over 20 million already have died Over 90% of people living with HIV/AIDS are in the developing world, with sub-Saharan Africa claiming the greatest number (25 million) and the greatest number of deaths (3 million) from AIDS Nonetheless, Asia now has the fastest-growing HIV/AIDS epidemic on earth, and sadly the advent of antiretroviral drugs has led to an increase in high-risk behavior in high-income countries, resulting in an increase in the number of new HIV infections While only time will reveal the full impact of HIV/AIDS on the human story, it is already certain that it has altered the future of Africa The pandemic has already reduced average national economic growth rates by 2 4% a year across Africa.

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